Prodiamine Herbicide

Prodiamine is a selective pre-emergent herbicide used to control grassy and broadleaf weeds.

Designed for easy application, it is mixed with water and sprayed to create a protective barrier on the soil surface, effectively preventing weed seeds from germinating and growing.

This herbicide is also available in a liquid flowable formulation under the name Prodiamine 4L. It differs from Prodiamine 65WDG only in its formulation.

Active Ingredient

The active ingredient in this herbicide is prodiamine, which is also the name used to identify the product. It is present at a concentration of 65% in the formulation.

How It Works

The herbicide works by creating a thin layer on top of the soil. When a weed seed tries to sprout, it cannot grow roots or leaves because the prodiamine stops the cells in the seed from dividing. This means the weed cannot grow, and it stays under the soil.

It doesn’t kill weeds that are already growing. It only stops new ones from coming up.

Where to Use

You can use Prodiamine 65WDG in a variety of areas to control grassy and broadleaf weeds effectively. It is suitable for use in:

Turfgrass settings such as lawns, sod farms, and established turf (excluding golf course putting greens).
Ornamental plant areas, including container-grown, field-grown, and landscaped ornamentals.
Tree nurseries, such as conifer and hardwood seedling nurseries.
Perennial and wildflower plantings, ensuring weed control in established beds.
Non-crop areas, including managed rights-of-way for transportation systems, utilities, and other infrastructure like roadways, roadsides, and railways.
Industrial and facility spaces, such as substations, tank farms, pumping stations, parking lots, storage areas, and ungrazed fence rows.
Christmas tree farms, to maintain weed-free growth around trees.

Weeds Controlled

This herbicide effectively controls a wide range of grassy and broadleaf weeds. Below is a list of the key types of weeds it targets:

Weeds Controlled (Tuf, Ornamentals)
Common Name	Scientific Name
Barnyardgrass	Echinochloa crus-galli
Betony, Florida	Stachys flordans
Bluegrass, Annual	Poa annua
Carpetweed	Mollugo verticillata
Chickweed, Common	Stellaria media
Chickweed, Mouseear (from seed)	Cerastium vulgatum
Crabgrass, Large	Digitaria sanguinalis
Crabgrass, Smooth	Digitaria ischaemum
Crowfootgrass	Dactyloctenum aegypticum
Cupgrass, Woolly	Eriochloa villosa
Foxtails, Annual	Setaria spp.
Goosegrass	Eleusine indica
Henbit	Lamium amplexicaule
Itchgrass	Rottboellia cochinchinensis
Jew, Wandering	Zebrian pendual
Johnsongrass (from seed)	Sorghum halepense
Junglerice	Echinochloa colonum
Knotweed	Polygonum spp.
Kochia	Kochia scoparia
Lambsquarters, Common	Chenopodium album
Lovegrass	Eragrostis spp.
Oxalis, Buttercup	Oxalis pes-caprae
Panicum, Texas	Panicum texanum
Panicum, Fall	Panicum dichotomiflorum
Panicum, Browntop	Panicum fasciculatum
Pigweed	Amaranthus spp.
Purslane, Common	Portulaca oleracea
Pusley, Florida	Richardia scabra
Rescuegrass	Bromus catharticus
Shepherdspurse	Capsella bursa-pastoris
Signalgrass, Broadleaf	Brachiaria platyphylla
Speedwell, Persian	Veronica persica
Sprangletop	Leptochloa spp.
Spurge, Prostrate	Chamaesyce humistrata
Vetch, Common	Vicia sativa
Witchgrass	Panicum capilla
Woodsorrel, Yellow (from seed)	Oxalis pes-caprae

Mixing Instructions

To ensure an even application, this herbicide must be thoroughly mixed in the spray tank. Follow these steps for proper preparation and use:

Fill the spray tank about 1/4 full with clean water or fluid fertilizer.
Start the agitation system and make sure it is functioning correctly.
Add Prodiamine 65WDG or Prodiamine 4L directly into the spray tank.
Continue adding the remaining carrier to reach the desired spray volume.
To improve accuracy, consider adding a spray colorant. This helps mark treated areas and reduces the chance of skips or overlaps.
Keep the agitation system running vigorously both before and during application to maintain a uniform spray mixture.
Do not allow the spray mixture to dry inside the tank. After completing the application, thoroughly clean the sprayer by flushing it with water and a detergent.

Tank Mixes

You can tank mix this herbicide with other products.

When mixing this herbicide with other components (carrier and pesticide partners), let each product fully dissolve before adding the next one. Keep the tank mixture agitated during both the mixing process and the application.

Mixing Order for Tank Mixtures

Water-soluble bags: Add any products packaged in water-soluble bags first. Keep the mixture agitated and wait until the bags completely dissolve and the product is fully dispersed before adding anything else.
Granules and powders: Add water-dispersible granules (WDG or WG) and wettable powders (WP) next. Continue agitation while adding them, and make sure they are fully dispersed before moving on.
Adjuvants and markers: Add spray adjuvants or spray markers at this stage. Always read the label of the adjuvant and only use products approved for turf and ornamental plants.
Flowable liquids: Add flowable liquids (FL) or suspension concentrates (SC).
Emulsifiable concentrates: Add emulsifiable concentrates (EC) last.

If you plan to do it, it is recommended to perform a jar test first to check compatibility.

Compatibility Test

Before mixing it with other pesticides in the spray tank, it’s important to test their compatibility. You can do this by mixing all the components (carrier and pesticide products) in a small container in the same proportions as the planned spray mix.

For Prodiamine 65WDG: if you are applying at a rate of 1 lb/acre, use a 1-quart jar, which represents 1/100th of the volume of a 25-gallon-per-acre spray rate. This would mean adding approximately 4.5 grams (or about 1.5 teaspoons) to the quart of water.

Prodiamine 65WDG – Amount of Component to Add to One Quart Jar of Spray Carrier
(Assuming Carrier Volume of 25 gals./Acre)
Components	Formulations	Rate Per Acre	Rate Per 1,000 Sq. Ft.	Level Teaspoons
Prodiamine 65WDG	Dry Tank Mix Partners	1.0 lb.	0.4 oz.	1.5
Prodiamine 65WDG	Liquid Tank Mix Partners	1.0 pt.	0.4 oz.	0.5

For Prodiamine 4L: if you are applying at a spray rate of 25 gallons per acre, use 1 quart to represent 1/100th of that volume. If the application rate is 1.0 pound per acre, you would add about 1 teaspoon of Prodiamine 4L to a quart of water.

Prodiamine 4L – Amount of Component to Add to One Quart Jar of Spray Carrier
(Assuming Carrier Volume of 25 gals./Acre)
Component Formulations	Rate Per Acre	Rate Per 1,000 Sq. Ft.	Level Teaspoons
Prodiamine 4L	21.0 fl oz	1.0 fl oz	1.0
Dry Tank-Mix Partners	1.0 lb	0.4 oz	1.5
Liquid Tank-Mix Partners	16 fl oz	0.5 fl oz	0.5

How to Use It

Using this herbicide requires careful preparation and proper steps to ensure safety and effectiveness.

Check the product label for specific instructions, rates, and precautions for your application area.
Always wear protective clothing, gloves, safety goggles, and a mask to protect yourself from exposure.
Check the weather and apply the herbicide when conditions are calm, with no rain expected for at least 24 hours.
Use a handheld, backpack, or boom sprayer that is suitable for your application area. Ensure the sprayer is clean and free from any residues of other chemicals to avoid contamination.
Prepare the mixture according to the label instructions and application rates. Slowly add the herbicide to the tank while the agitator or mixing wand is running.
Calibrate your sprayer and start walking at a steady pace or move your equipment consistently, ensuring even coverage of the entire area. Avoid overlapping spray patterns to prevent over-application.
After completing the application, lightly water the treated area with 0.5 inches (1.25 cm) of irrigation or rainfall to activate the herbicide in the soil.
Thoroughly rinse your sprayer with water and a small amount of detergent. Flush the system completely to prevent clogging or contamination for future use. Finally, wash your hands, face, and any exposed skin with soap and water after application.

Use for Established Turf

Application Rates

Maximum Application Rate of Prodiamine 65WDG Per Calendar Year by Turfgrass Species
Turf Species	Lbs. of Product/Acre	Oz. of Product/1,000 Sq. Ft.	Area Treated Per Water Soluble Packet (Sq. Ft.)
Bermudagrass² Bahiagrass Centipedegrass Kikuyugrass Seashore Paspalum St. Augustinegrass³ Tall Fescue (including turf-type) Zoysiagrass	1.0 – 2.30¹	0.36 – 0.83	22,000 – 9,600
Buffalograss Kentucky Bluegrass Perennial Ryegrass	0.5 – 1.50¹	0.185 – 0.55	44,000 – 14,700
Fine Fescue	0.5 – 1.15¹	0.185 – 0.42	44,000 – 19,100
Creeping Bentgrass (0.5 inches or more in height)⁴	0.5 – 1.00¹	0.185 – 0.37	44,000 – 22,000

¹Prodiamine 65WDG can be applied multiple times within a year, provided the total amount used does not exceed the maximum annual application rate specified for the turf species. Ensure all applications are made before the weed seeds begin to germinate.

²It can be applied to newly sprigged or plugged Bermudagrass at rates no higher than 0.80 lb./A (0.30 oz./1,000 sq. ft.).

³Apply an initial rate of 0.75–1.5 lbs./acre (0.28–0.55 oz./1,000 sq. ft.) per application.

⁴To prevent turf injury, avoid applying Prodiamine 65WDG to creeping bentgrass that is mowed to a height of less than 0.5 inches.

Maximum Application Rate of Prodiamine 4L Per Calendar Year by Turf Species
Turf Species	Fl Oz Product/Acre¹	Fl Oz Product/1,000 Sq Ft¹
Bermudagrass Bahiagrass Centipedegrass Kikuyugrass Seashore Paspalum St. Augustinegrass Tall Fescue (including turf-type) Zoysiagrass	21-48	0.5-1.1
Buffalograss Kentucky Bluegrass Perennial Ryegrass	10-30	0.23-0.70
Fine Fescue	10-24	0.23-0.55
Creeping Bentgrass (0.5 inch or more in height)	10-21	0.23-0.48

¹Prodiamine 4L may be applied multiple times within a year, provided the total amount does not exceed the maximum application rate specified for each turf species.

This product can harm young plants if their roots have not grown at least two inches deep into the soil. To avoid damaging overseeded turf, wait 60 days after planting or until the grass has been mowed twice, whichever takes longer, before applying the product.

Use Restrictions

Avoid applying Prodiamine 65WDG to areas where dichondra, colonial bentgrass, velvet bentgrass, or annual bluegrass (Poa annua) are preferred or desired.
Do not harvest sod treated with this herbicide until at least 90 days after application. To prevent damage, ensure that the newly laid sod is fully rooted and that the edges have grown in before applying the product.

Turfgrass Use Precautions

Do not apply Prodiamine 65WDG to turfgrass under stress from drought, poor soil nutrients, or pest damage, as this may result in injury to the turf.
Activities like disking or other soil disturbances can break the herbicide barrier and reduce its ability to control weeds effectively.
Shallow roots in creeping bentgrass can come into contact with herbicide-treated soil, potentially inhibiting new root growth. Mowing height affects root depth, so avoid applying Prodiamine 65WDG to creeping bentgrass that is cut to a height of less than 0.5 inches.

Use in Ornamental Plantings, Christmas Tree Farms

In these areas, you can use this herbicide on both newly transplanted and established ornamentals as a broadcast or over-the-top spray.

Before applying it, prepare the soil by clearing it of debris, leaves, or mulch. Additionally, to activate the herbicide, ensure the treated area receives at least 0.5 inches (1.25 cm) of water through irrigation or rainfall, or incorporate it into the soil shallowly (1 to 2 inches or 2.5 to 5 cm).

Application Rates

Prodiamine 65 WDG – Application Rates and Timing
Amount to Apply (Broadcast)*	When to Apply	Comments/Instructions
1.0 – 2.3 lbs./acre or 0.37 – 0.83 oz./1,000 sq. ft.	In the fall or spring before weeds germinate or after weeds are removed	Use the higher rate for longer control. Prodiamine 65WDG may be applied more than once per year, provided the total amount does not exceed 2.3 lbs./acre per year.

**Prodiamine 4L – Application Rates and Timing**
Amount to Apply (Broadcast)*	When to Apply	Comments/Instructions
21-48 fl oz/acre or 0.5-1.1 fl oz/1,000 sq ft	In fall or spring before weeds germinate or after weeds are removed.	Use the higher rate for longer control. Prodiamine 4L can be applied more than once per year, as long as the total amount applied does not exceed 48 fl oz/acre (1.5 pounds active ingredient/acre) per year.

Tank Mixtures in Ornamental Plantings

For container, field-grown, and landscape ornamentals, Prodiamine 65WDG can be mixed with the following tank partners: Goal, Galigan (for conifers only), Gallery, Princep, Pennant, Touchdown Pro, Reward, and Finale.

If using the liquid formulation Prodiamine 4L, it can be mixed with Galigan (for conifers only), Quali-Pro Isoxaben 75WG, Princep, MANA Parallel, Glyphosate, and Finale.

Use in Non-Crop Areas

This herbicide is ideal for maintaining clean and weed-free environments, as it provides long-lasting control and reduces maintenance efforts.

Weeds Controlled in Vegetation Management

Weeds Controlled in Vegetation Management
Weed Name
Barnyardgrass
Kochia
Bluegrass, Annual (Poa annua)¹
Lambsquarters, Common
Carpetweed
Lovegrass
Chickweed, Common¹
Panicum (Texas, Fall, Browntop)
Chickweed, Mouseear (from seed)
Pigweed
Crabgrass (Large, Smooth)³
Purslane, Common
Crowfootgrass
Pusley, Florida
Cupgrass, Woolly
Rescuegrass²
Foxtails, Annual
Shepherdspurse¹
Goosegrass³
Signalgrass, Broadleaf
Henbit¹
Speedwell, Persian
Itchgrass
Sprangletop
Johnsongrass (from seed)
Spurge, Prostrate
Junglerice
Witchgrass
Knotweed¹
Woodsorrel, Yellow (from seed)

¹To control this weed, apply Prodiamine 65WDG in late summer, fall, or winter before weed seeds germinate.

²Suppression only.

³Sequential applications may be made as long as the total amount of 65 WDG applied does not exceed 2.3 lbs./A per year.

Application Rates

Prodiamine 65WDG – Application Rates and Instructions
Amount to Apply (Broadcast)*	When to Apply	Comments/Instructions
1.0-2.3 lbs./A or 0.37-0.83 oz/1,000 sq. ft.	In fall and/or spring before weeds germinate or after weeds are removed.	Use the higher rate for longer control. Prodiamine 65WDG may be applied more than once per year, provided the total amount does not exceed 2.3 lbs./A per year.

**Prodiamine 4L – Application Rates and Instructions**
Site	Application Rate	Timing	Comments/Instructions
Non-crop areas, including ornamentals, on or surrounding managed rights-of-way for transportation systems and utilities (including roadways, roadsides, railways, and equipment yards); facilities including substations, tank farms, pumping stations, parking and storage areas, and non-grazed fence rows.	21 – 48 fl oz/acre or 0.5-1.1 fl oz/1,000 sq ft	Before weed seeds germinate	Use the higher rate range for longer control. More than one application per year is allowed, but the total amount applied must not exceed 48 fl oz/acre (1.5 pounds active ingredient per acre) per year.

Tank Mixtures in Non-Crops

Prodiamine 65WDG can be mixed with the following tank partners for use in non-crop areas: Goal, Galigan (for conifers only), Gallery, Princep, Pennant, Touchdown Pro, Reward, and Finale.

Prodiamine 4L can be mixed with various products to enhance weed control, including glyphosate-based products (e.g., Glyphogan), paraquat-based products (e.g., Parazone 3SL), diuron-based products (e.g., Diuron 4L), and oryzalin-based products (e.g., Oryzalin 4AS). It can also be combined with Reward, Predict, Princep, Vanquish, Finale, Quali-Pro Isoxaben 75 WG, Garlon, Krovar I and II, Oust, Arsenal, Spike, and Telar.

Use Restrictions

When using this product, keep the following restrictions in mind to ensure safe and effective application:

No grazing or feeding: Livestock cannot graze or be fed forage harvested from areas where this product has been applied.
Food crops restriction: Do not use it on plants intended for human or animal consumption.
No dry blending: You cannot mix it with dry fertilizers or other granular materials.
Irrigation systems: Do not apply this product through irrigation systems unless the label specifically states it is allowed.
No aerial application: You cannot apply it using aircraft.
Golf course greens: Do not use this product on golf course putting greens.
For Prodiamine 4L, the application rate must not exceed 1.5 pounds of active ingredient per acre (equivalent to 48 fl oz per acre) annually for any use site.

EPA Registration Number

The EPA registration number of for the Prodiamine 65WDG is: 53883-429.

The EPA registration number of for the Prodiamine 4L is: 53883-379.

Ornamental Plants Safe for Herbicide Application

Although it is a herbicide, more than 200 plants can safely tolerate its application without being harmed. This information is essential for users to determine which ornamental plants can be treated with the herbicide and in which settings, such as containers, fields, or landscapes.

Table of Tolerant Ornamental Species
Common Name	Scientific Name
Fir species (Balsam, Fraser, Noble, etc.)	Abies spp.
Japanese Maple	Acer palmatum
Norway Maple	Acer platanoides
Kiwi	Actinidia chinensis
Lily-of-the-Nile (African Lily)	Agapanthus africanus
Vine Hill Manzanita	Arctostaphylos densiflora
Cape Weed	Arctotheca calendula
Japanese Aucuba	Aucuba japonica
Barberry	Berberis gladwynensis
Wintergreen Barberry	Berberis julianae
Mentor Barberry	Berberis mentorensis
Japanese Barberry	Berberis thunbergii
Warty Barberry	Berberis verruculosa
Japanese Boxwood	Buxus microphylla
Weeping Bottlebrush	Callistemon viminalis
Scotch Heather	Calluna vulgaris
Hottentot Fig (Ice Plant)	Carpobrotus edulis
Feathery Cassia	Cassia artemisoides
Wild-Lilac	Ceanothus rigidus
False Cypress	Chamaecyparis pisifera
Cleyera	Cleyera japonica
Citrus species	Citrus spp.
Flowering Dogwood	Cornus florida
American Dogwood	Cornus stolonifera
Pampas Grass	Cortaderia selloana
Cranberry Cotoneaster	Cotoneaster apiculatus
Cotoneaster	Cotoneaster buxifolius
Bearberry Cotoneaster	Cotoneaster dammeri
Rockspray Cotoneaster	Cotoneaster microphyllus
Hawthorne	Crataegus spp.
Italian Cypress	Cupressus sempervirens
White Trailing Ice Plant	Delosperma alba
Hop Bush	Dodonea viscosa
Silverberry	Elaeagnus pungens
Wintercreeper	Euonymus fortunei
Japanese Spindle Tree (Evergreen Euonymus)	Euonymus japonica
Spreading Euonymus	Euonymus kiautschovica
Japanese Aralia	Fatsia japonica
Border Forsythia	Forsythia intermedia
Greenstem Forsythia	Forsythia viridissima
Gardenia, Cape-Jasmine	Gardenia jasminoides
Gladiolus species	Gladiolus spp.
English Ivy	Hedera helix
Rose of Sharon	Hibiscus spp.
Chinese Hibiscus	Hibiscus Rosa-sinensis
Chinese Holly	Ilex cornuta
Japanese Holly	Ilex crenata
American Holly	Ilex opaca
Holly	Ilex pernyi
Yaupon Holly	Ilex vomitoria
Iris species	Iris spp.
Winter Jasmine	Jasminium nudiflorum
Chinese Juniper	Juniperus chinensis
Shore Juniper	Juniperus conferta
Creeping Juniper	Juniperus horizontalis
Walnut	Juglans spp.
Shrimp Plant	Justicia brandegeana
Crape Myrtle	Lagerstroemia indica
Amur Privet	Ligustrum amurense
Japanese Privet	Ligustrum japonicum
Glossy Privet (Wax-leaf)	Ligustrum lucidum
Big Blue Lilyturf	Liriope muscari
Japanese Honeysuckle	Lonicera japonica
Tatarian Honeysuckle	Lonicera tatarica
Magnolia species	Magnolia spp.
Ice Plant	Maleophora luteola
Crabapple	Malus spp.
Heavenly Bamboo	Nandina domestica
Narcissus species	Narcissus spp.
Oleander	Nerium spp.
Olive	Olea europaea
Mondo Grass	Ophiopogon japonicus
Trailing African Daisy	Osteospermum fruticosum
Sourwood	Oxydendrum arboreum
Avocado	Persea americana
Frasier’s Photinia (Redtip)	Photinia fraseri
Spruce species (Colorado Blue, Norway, etc.)	Picea spp.
Lily-of-the-Valley Shrub	Pieris japonica
Calabrian Pine	Pinus brutia
Canary Island Pine	Pinus canariensis
Slash Pine	Pinus elliottii
Aleppo Pine	Pinus halepensis
Austrian Black Pine	Pinus nigra
Longleaf Pine	Pinus palustris
Monterey Pine	Pinus radiata
Eastern White Pine	Pinus strobus
Scotch Pine	Pinus sylvestris
Loblolly Pine	Pinus taeda
Japanese Black Pine	Pinus thunbergiana
Virginia Pine	Pinus virginiana
Pistachio	Pistacia spp.
Queensland Pittosporum	Pittosporum rhombifolium
Japanese Pittosporum	Pittosporum tobira
Japanese Yew	Podocarpus macrophyllus
English Laurel	Prunus laurocerasus
Almond, Apricot, Nectarine, Peach, Plum, Prune	Prunus spp.
Douglas Fir	Pseudotsuga menziesii
Firethorn, Scarlet	Pyracantha coccinea
Firethorn, Chinese	Pyracantha fortuneana
Firethorn, Formosa	Pyracantha koidzumii
Bradford Pear	Pyrus spp.
Oak species	Quercus spp.
Indian Hawthorne	Raphiolepis indica
‘Coral Bells’	Rhododendron (including Azalea)
Lady Bank’s Rose	Rosa banksiae
Rosemary	Rosmarinus officinalis
Leatherleaf Fern	Rumohra adiantiformis
Japanese Boxcherry	Syzygium paniculatum
Japanese Yew	Taxus cuspidata
Yew	Taxus media
American Arborvitae	Thuja occidentalis
Star Jasmine	Trachelospermum asiaticum
Canada Hemlock	Tsuga canadensis
Tulip species	Tulipa spp.
Japanese Viburnum	Viburnum japonicum
Sweet Viburnum	Viburnum odoratissimum
Japanese Snowball	Viburnum plicatum
Canary Island Viburnum	Viburnum rigidum
Laurustinus	Viburnum tinus
Cranberry Bush	Viburnum trilobium
Leatherleaf Viburnum	Viburnum wrightii
Vinca	Vinca major
Dwarf Periwinkle	Vinca minor
Grape	Vitis spp.
Old Fashioned Weigela	Weigela florida
Spanish Bayonet	Yucca aloifolia
Yucca, Adam’s Needle	Yucca filamentosa